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KMID : 1134820100390121783
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Journal of the Korean Society of Food Science and Nutrition
2010 Volume.39 No. 12 p.1783 ~ p.1789
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Effect of Onion Extracts on Serum Cholesterol in Borderline Hypercholesterolemic Participants
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Lee Hyun-Jin
Lee Kyung-Hea
Park Eun-Ju
Chung Hye-Kyung
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Abstract
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The aim of this study was to examine the effects of 10 week onion extract supplementation on blood lipid profiles in borderline hypercholesterolemic participants. The study consisted of 10 males and 17 females aged 45.9±10.0 years. At baseline, serum total cholesterol level was 228.6±4.1 ㎎/dL (201～239 ㎎/dL). This study was designed as randomized single blind placebo controlled cross-over study. After 1 week wash-out period, subjects were randomized into two groups; they took onion extract (150 mL/1 pack, containing 30 mg quercetin) or placebo for 10 weeks. After 1 week wash-out period again, subjects took exchanged samples for another 10 weeks. The total-cholesterol (226.7±4.6 → 206.8±3.6 mg/dL; p＜0.01), LDL-cholesterol (151.6±5.0 → 127.1±4.1 ㎎/dL; p＜0.01) and atherogenic index (AI: 4.0±0.3 → 3.4±0.2; p＜0.05) decreased significantly after 10 weeks of onion extracts supplementation, while there were no significant changes during placebo periods. The levels of HDL-cholesterol (onion extract: 46.5±2.0 → 50.2±2.1 ㎎/dL, placebo: 47.8±2.1 → 50.1±2.4 ㎎/dL), GOT (onion extract: 36.8±1.8 → 32.3±1.8 IU/L, placebo: 35.1±2.1 → 32.8±2.0 IU/L), and GPT (onion extract: 36.5±3.2 → 32.9±1.8 IU/L, placebo: 36.6±3.8 → 33.8±2.8 IU/L) showed no significant changes in both periods. These results indicate that the consumption of onion concentrated extracts exerts beneficial effects on dyslipidemia through the decrease of serum total cholesterol and LDL cholesterol levels in borderline hypercholestrolemic subjects. In conclusion, onion was useful as dietary therapy for hypercholestrolemia and adequate onion intake may help to prevent cardiovascular disease.
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KEYWORD
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onion extract, quercetin, cholesterol, atherogenic index (AI), hypercholesterolemia
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